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Not with the basic reward program which only allows cardholders to earn points from shopping at a variety of retailers. However, there is a Plenti Amex credit card branded by American Express. This is a traditional charge card and can be used for whatever purchases a cardholder would like anywhere it is accepted. However, you do not need to apply for the American Express card or even have good credit to get it. Home Depot does participate in the reward program. So you can get rewards for shopping there, however, to charge or finance items there you will need a credit card. Also rewards are only earned at Home Depot when shopping through the Marketplace at Marketplace. So you will not earn rewards for any Home Depot in-store purchases.