Jetblue Business credit card comes with $99 annual fee that is not waived for the first year, so you have to pay it straight away. This credit card comes with different benefits: good sign-up bonus, rewards, travel benefits like free first checked bag, in-flight savings and business benefits. So you should use your credit card often to earn more points and travel a lot to use travel benefits to justify the annual fee.
If you do not want to pay annual fee, you may consider travel rewards credit cards with no annual fee. For example, the Discover it® Miles is a good choice. You will earn unlimited 1.5x miles for every dollar spent on all purchases all with no annual fee. Discover will match ALL the miles you’ve earned at the end of your first year, automatically (proveided you are a new cardmember). For example, if you earn 30,000 miles, you get 60,000 miles. That’s $600 towards travel! Miles can be redeemed for any flight, including JetBlue flights.