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For sure, you can save on Expedia bookings using general rewards credit card. Expedia credit cards also allow you to save on bookings, but they are useful for those who often use Expedia service - you can earn up to 4x points on eligable Expedia bookings purchases, depending on the credit card. Points are redeemable towards your stay at a VIP Access™ hotel. If you have no need to make a lot of hotel bookings, the rewards these cards offer won't be of much use.

If you want to save on Expedia bookings and other travel purchases, you may consider travel rewards cards from major banks to save on your next travel. Earned miles can be redeemed for Expedia purchases and you can earn miles on every purchase you make. Travel cards often comes with sign-up bonuses and other perks.

For example, the Discover it® Miles card is a good option. You will earn unlimited 1.5x miles on all purchases. All the miles you've earned at the end of the first year will be matched (this option is for new cardmembers only). This means, if you earn 35,000 miles, you will get 70,000 miles. You can redeem miles for any flights and other travel expenses, including Expedia bookings. Earned miles never expire and you have no limit to how much you can earn.